Fine mapping the TAGAP risk locus in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Rheumatoid arthritis: mapping the future.
R heumatoid arthritis (RA) is a common autoimmune condition presenting with symmetric polyarticular arthritis and affecting 0.5% to 1.0% of the population (2). It is associated with significant and progressive disability, extra-articular systemic complications, high socioeconomic costs, and early death (3). Cardiac manifestations occur in up to 60% of patients with RA and include pericarditis, ...
متن کاملIdentification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis
OBJECTIVE To fine-map the NF-κB activating protein-like (NKAPL) locus identified in a prior genome-wide study as a possible rheumatoid arthritis (RA) risk locus and thereby delineate additional variants with stronger and/or independent disease association. METHODS Genotypes for 101 SNPs across the NKAPL locus on chromosome 6p22.1 were obtained on 1368 Canadian RA cases and 1471 controls. Sing...
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The IDDM8 region on chromosome 6q27, first identified as a susceptibility locus for type 1 diabetes, has previously been linked and associated with rheumatoid arthritis (RA). The region contains a number of potential candidate genes, including programmed cell death 2 (PDCD2), the proteosome subunit beta type 1 (PSMB1), delta-like ligand 1 (DLL-1) and TATA box-binding protein (TBP) amongst other...
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Background: Changes in patients’ bone mineral density (BMD) is one of the problems in patients with rheumatoid arthritis, which can be due to the use of corticosteroid drugs to reduce patients' symptoms or due to the aging process in patients. In this study, we decided to compare BMD in patients with psoriatic arthritis and rheumatoid arthritis. Methods: This study as a cross-sectional descrip...
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Considerable sharing of disease alleles among populations is well-characterized in autoimmune disorders (e.g., rheumatoid arthritis), but there are some exceptional loci showing heterogenic association among populations. Here we investigated genetic variants with distinct effects on the development of rheumatoid arthritis in Asian and European populations. Ancestry-related association heterogen...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2011
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2011.8